EVALUATION OF HAIR GROWTH PROMOTING ACTIVITY OF INDIGOFERA TINCTORIA LINN. IN MALE WISTAR RATS
Vishal Lad*, Chandrakant Suryawanshi, Amit Sinhal, Tushar Salunkhe, Vinod Wagh and Gopichand Bhoi
ABSTRACT
Alopecia is a dermatological disorder with psychosocial implications
on patients with hair loss. Indigofera tinctoria Linn. is a well-known
Ayurvedic herb with purported claims of hair growth promotion. In the
reported work attempts were undertaken to evaluate petroleum ether
and ethanol extract of Indigofera tinctoria Linn. for their effect on
promoting hair growth in albino wistar rats. The extracts were
incorporated into oleaginous cream (water in oil cream base) and
applied topically on shaved denuded skin of albino rats. The time (in
days) required for hair growth initiation as well as completion of hair
growth cycle was recorded. Minoxidil 2% solution was applied topically and served as
positive control for comparison. Hair growth initiation time was significantly reduced to half
on treatment with the extracts, as compared to control animals. The time required for
complete hair growth was also significantly reduced. Quantitative analysis of hair growth
after treatment with petroleum ether extract (5%) exhibited greater number of hair follicles in
anagenic phase, which were higher as compared to control. The result of treatment with 2 and
5% petroleum ether extracts were better than the positive control minoxidil 2% treatment.
Keywords: Alopecia, Hair growth, Indigofera tinctoria, Anagen, Telogen, Minoxidil.
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