Abstract

COLON TARGETED DRUG DELIVERY SYSTEM:- A REVIEW

Bhandari Neeraj*, Tangum, Bali Tanvi, Simran, Sumeena and Choudhary Swati

ABSTRACT

Targeted drug delivery to the colon is highly desirable for local treatment of variety of bowel diseases such as ulcerative colitis, crohan’s disease amebiosis, colonic cancer and for local treatment of local colonic pathologies and the systemic delivery of protein and peptide drugs. Colon targeting is apparently useful for systemic action of protein – peptide drugs such as insulin, calcitonin and metenkaphalin and even for other nonpeptide drugs such as cardiovascular and antiasthmatic agents describes approaches used for colon targeting. The colonic delivery is also beneficial in the systemic absorption of drugs like nifedipine, theophylline, isosorbide, etc. The successful delivery of drugs to the colon via the gastrointestinal tract requires the protection of a drug from being released in stomach and small intestine. The simplest method for targeting of drugs to the colon is to obtain slower release rates or longer release periods by the application of thicker layers of conventional enteric coating or extremely slow releasing matrices.[1] There are various methods or techniques through which colon drug targeting can be achieved for example, formation of prodrug, coating with pH sensitive polymers, designing formulations using polysaccharides, coating with biodegradable polymers, timed released systems, osmotic pressure controlled systems. Coating of the pH – sensitive polymers provides simple approach for colon – specific drug delivery.[2]

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