Photo Gallery

Login

Search

News & Updation

  • Updated Version
  • WJPPS introducing updated version of OSTS (online submission and tracking system), which have dedicated control panel for both author and reviewer. Using this control panel author can submit manuscript
  • Call for Paper
    • WJPPS  Invited to submit your valuable manuscripts for Coming Issue.
  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.
  •  
  • WJPPS Impact Factor
  • Its our Pleasure to Inform you that WJPPS Impact Factor has been increased from  7.454 to 7.632  due to high quality Publication at International Level

  • ICV
  • WJPPS Rank with Index Copernicus Value 84.65 due to high reputation at International Level

  • WJPPS JANUARY ISSUE PUBLISHED
  • JANUARY 2020 Issue has been successfully launched on 1 January 2020.

Abstract

PRE-ADMINISTRATION OF CURCUMIN PREVENTS HYPERHOMOCYSTEINEMIA IN ETHANOL-INDUCED GASTRIC ULCER

Jihan Hussein*, Tay E Abdel Razik and Mona El-Banna

ABSTRACT

Curcumin is a prototype natural product that has been widely recognized as an antioxidant and anti-inflammatory agent. In this study, we aimed to evaluate the potential role of curcumin supplementation in attenuating the aggressive effect of alcohol in experimental induced gastric ulcer. Forty male albino rats weighing 150-180 g were classified into four groups including control, curcumin, ethanol and treated groups. Oxidant and antioxidant parameters were estimated, liver and kidney function were measured, tumor necrosis factor - α (TNF-α) was determined by ELISA and homocysteine was estimated by HPLC using reversed phase column and UV detector that was performed at 260 nm. Stomach malondialdehyde (MDA) and nitric oxide (NO) levels were significantly increased by ethanol consumption compared to control group beside the reduction of reduced glutathione (GSH) and the elevation of homocysteine and TNF-α. Whereas, pre- treatment of curcumin prevented the hyperhomocysteinemia and the elevation of TNF- α resulting in a depletion of gastric ulcer. We concluded that, curcumin is considered a promising supplement in attenuating gastric ulcer through its important role in depletion of oxidative stress and inflammation.

Keywords: gastric ulcer, curcumin, hyperhomocysteinemia, HPLC, ethanol.


[Full Text Article]

Call for Paper

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Online Submission

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Email & SMS Alert

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More