Abstract

DEVELOPMENT OF GASTRO RETENTIVE FLOATING MATRIX TABLETS OF NORFLOXACIN

Middela Karthik*, P. Swetha and Dr. Anna Balaji

ABSTRACT

This study was conducted to develop gastro retentive floating tablets for Norfloxacin. In present study floating tablets were prepared by using polymers as floating agents so as to maintain in buoyancy condition for about 12 hours to achieve maximum bioavailability and to produce local bioavailability. Floating tablets were developed by using polymers i.e., Hydroxy Propyl Cellulose (HPC), Chitosan and Caragennan Gum. Various precompression parameters were evaluated for formulation blend including Drug excipient compatibility studies by using FTIR studies. Calibration curve was plotted by usin 0.1 N HCL as medium. The prepared formulations were evaluated for various post compression parameters like hardness, friability, thickness, weight variation, floating lag time floating buoyancy studies and in vitro dissolution studies. Among all the formulations F2 formulation which contains polymer Hydroxy Propyl Cellulose (HPC) has shown desired percentage drug release in 12 hours. The In vitro dissolution data were fitted in different kinetic models viz. zero order, first order, Higuchi and Korsemeyer - Peppas equation. Correlation coefficients of formulation F2 showed higher correlation with Higuchi R2 = 0.991.

Keywords: Floating drug delivery system, Norfloxacin, Floating Tablets.