Abstract

DESIGN OF DUAL RELEASE DRUG DELIVERY SYSTEM OF ASPIRIN AND ATORVASTATIN FOR CARDIOVASCULAR DISEASES

Reshma Fathima K.*, Rahul Krishnan P. R.

ABSTRACT

Combined drug therapy (CDT) is favoring for most of the treatment, and aim of the therapy is to decrease or reduce dose dependent adverse drug reactions and side effects. The present work an attempt to design bilayer tablets of Atorvastatin immediate release and Aspirin Pulsatile release for the treatment of cardiovascular diseases. Four formulations were prepared for immediate release layer of atorvastatin using different concentrations of Microcrystalline cellulose and Talc by direct compression method. For aspirin pulsatile release layer, the four formulations of core tablets were prepared using Microcrystalline cellulose, Talc. The different concentrations of Cross carmellose sodium and Sodium starch glycolate were selected as superdisintegrants in F1, F2 and F3, F4 formulations. Then the core tablets were coated with Eudragit S 100 as enteric polymer. Physico chemical parameters of bilayer tablets were performed and it has shown a good drug release profile. The work reveals that F3 formulation was the best formulation and they are the good candidate for lowering the risk of heart attack. Pattern like one layer of the formulation as immediate release to reduce the cholesterol level and the second layer to deliver the drug at right time and in right amount, to reduce the risk of heart attack.

Keywords: Combined drug therapy, Pulsatile drug release, Aspirin, Atorvastatin, Cardiovascular diseases, Bilayer tablets.