Abstract

NOVEL SYNTHESIS OF 8, 9-DIHYDRO- 7H-BENZO 4-METHYL-2-OXO-2H-8-CHROMENYL] 5-ARYL-4, 5-DIHYDRO-4-ISOXAZOLE CARBOXYLATES

Dr. A.L.V. Ramana Reddy*

ABSTRACT

8, 9-dihydro- 7h-benzo -4-methyl-coumarin aldehyde chlorooxime (4) on reaction with in the presence of polyphosperic acid reflus for 24 hours to gave 8, 9-dihydro- 7h-benzo chloro-4-methyl-2-oxo-2H-8-chromenyl]-5-phenyl-4,5-dihydro-4-isoxazole carboxylate (5a-h) in a good yields. The structures of all the newly synthesized molecules were assigned by elemental analysis and spectral data. The synthesized compounds were screened for their antibacterial activities strains using Cup plate method.

Keywords: 7-Benzyloxy-4-methyl-coumarin aldehyde chlorooxime, triethylamine in chloroform, aldehyde chlorooxime, antibacterial activity.