Abstract

EMULGEL OF MOXIFLOXACIN HCL SOLID LIPID NANOPARTICLES FOR TOPICAL APPLICATION

Om Shelke* and Amol Kulkarni

ABSTRACT

Moxifloxacin HCl is ophthalmic antibiotic used for eye infections. An attempt has been made to formulate the Solid Lipid Nanoparticles (SLNs) and SLNs are entrapped in emulgel for controlled drug release for longer time. SLNs are formulated using cold homogenization method using Glyceryl behenate, Phospolipon 90H, Oleic acid, Palmitic acid, Polysorbate 20, Span 80, Propylene glycol and Purified water. SLNs were evaluated for particle size distribution, entrapment efficacy and in-vitro drug release. Formulated SLNs with highest entrapment efficacy and drug release were entrapped in emulgel. Emulgel were formulated using Butylated hydroxytoluene, Isopropyl Palmitate, Mineral Oil, Span 80, Polysorbate 20, Carbopol 980, Carbopol 934, Sodium Benzoate, Sodium hydroxide and Purified Water. Emulgel formulation were characterize for physical and chemical evaluation. Low viscosity (Carbopol 934) and high viscosity (Carbopol 980) Carbomer grades were compared. Both the grade Carbopol formulation has shown good stability at accelerated and room temperature storage condition. The drug release with high viscosity grade Carbopol 980 has maintained drug release through stability study.

Keywords: Moxifloxacin HCl, Solid Lipid Nanoparticles, Emulgel, Topical Application.