Abstract

DESIGN AND CHARACTERIZATION OF METFORMIN NANOSUSPENSION BY NANOPRECIPITATION METHOD

Viraj V. Upsham*, Krutika V. Ghate and Nandkishor S. Talware

ABSTRACT

Present study was to prepare Metformin nanosuspension and characterization of nanosuspension and the main aim behind to formulate was to increase the permeability of the drug as it belongs to BCS class III. Metformin was selected and was found to increase the in vitro diffusion and partition coefficient of the drug. It was prepared by Nanoprecipitation method with high speed homogenizer by using different ratio of stabilizer: polymer. The formulation with the high stabilizer: polymer ratio shows the reduced particle size, more diffusion rate, high % production yield and % entrapment efficiency. The formulations were analysed for FTIR, DSC, PDI, Zeta potential, XRD, SEM and stability studies. The average particle size of optimized batch of nanosuspension was found to be 399nm.

Keywords: Nanosuspension, Metformin, Nanoprecipitation, High speed homogenizer, Partition coefficient.