Abstract

FLOATING DRUG DELIVERY SYSTEMS: A NOVEL APPROACH

Chandan Kumar Singh*, Shivanshu Pandey and Ayush Chandra Mishra

ABSTRACT

Oral route is widely acceptable and invulnerable route for administration of drugs, but there are also so many problems and challenges in safe delivery of medicament. The gastric emptying time and the variation in PH in different segments of gastrointestinal tract (GIT) are the major challenge task for the development of oral controlled release drug delivery system. Various attempt have been made to enhance the residence time of the dosage form within the stomach. Floating drug delivery systems (FDDS) improves the drug bioavailability and patient compliance by increasing the gastric residence time and controlling the drug release. Floating systems or dynamically controlled systems are low density systems that have sufficiently buoyancy to float over the gastric contents and remain buoyant in the stomach without affecting the gastric emptying rate for a prolonged period of time. This result in an increased gastric retention time and a better control of the fluctuations in plasma drug concentration. The goal of any drug delivery system is o provide a therapeutic mount of drug to proper site in the body to achieve immediately and then maintain a desired drug concentration. The favored point of Floating drug delivery systems over the conventional drug delivery system are reduced frequency of dosing, reduced counter activity of the body, minimized adverse activity at the colon and many moves. The purpose of writing this review on floating drug delivery systems (FDDS) was to focus on the principle mechanism of floatation to achieve gastric retention. The recent developments of FDDS including the physiological and formulation variables affecting gastric retention, approach to design single unit and multiple unit floating systems, their classification, formulation aspects, applications and evaluation are covered in detail.

Keywords: Floating Drug Delivery System, Gastric Residence Time, Evaluation, Application of FDDS.