Abstract

SELF EMULSIFYING DRUG DELIVERY SYSTEM: A REVIEW

Jayshree Sundaria*, Arushi Vasisth and S.K. Garg

ABSTRACT

The oral route is the easiest and most popular route of drug administration, being noninvasive and cost-effective. But the major problem in oral drug formulations is low dissolution and low bioavailability, which mainly results from poor water solubility. The improvement of drug solubility and bioavailability are the greatest challenges in formulations. The self-emulsifying drug delivery system (SEDDS) is a new approach for enhancing the solubility of formulations. SEDDS are an isotropic mixture of oil, surfactant, and co-surfactant with a unique ability to form fine oil-in-water (o/w) emulsions or microemulsions upon mild agitation in the gastrointestinal tract which present the drug in a solubilized form, and the small size of formed droplet provides a large interfacial surface area for drug absorption. This review gives a complete overview of SEDDS but special attention has been paid to formulation design and evaluation of SEDDS.

Keywords: Self Emulsifying Drug Delivery System, Oral bioavailability, Oils, Surfactants, Co-surfactants.