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World Journal of Pharmacy and
Pharmaceutical Sciences

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology

Impact Factor : 8.025

ICV : 84.65

WJPPS Citation

	All	Since 2019
Citation	5450	3969
h-index	23	20
i10-index	134	84

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WJPPS introducing updated version of OSTS (online submission and tracking system), which have dedicated control panel for both author and reviewer. Using this control panel author can submit manuscript

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New Impact Factor

WJPPS Impact Factor has been Increased to 8.025 for Year 2024.

WJPPS Rank with Index Copernicus Value 84.65 due to high reputation at International Level

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WJPPS is indexed in Scope Database based on the recommendation of the Content Selection Committee (CSC).

WJPPS: NOVEMBER ISSUE PUBLISHED

NOVEMBER 2024 Issue has been successfully launched on 1 NOVEMBER 2024.

Abstract

A NOVEL SYNTHESIS OF CEFIXIME FROM 7-AMINO-3-VINYL CEPHALOSPORANIC ACID (7-AVCA)

Nguyen Khanh Tan and Doan Ngoc Nhuan*

ABSTRACT

The present invention relates to simple and easy process for the preparation of cefixime. 7-amino-3-vinyl cephalosporanic acid (7-AVCA) is reacted with 2-mercapto-1,3-benzothiazolyl-(Z)-2-(3-aminothiazol-4-yl)-2-(methoxy carbonyl)-methoxyimino acetate (MICE) in tetrahydrofuran and water mixture at 0-4oC in the presence of triethanolamine. The novel feature of this study was the use of triethanolamine replaced triethylamine in the activation reaction between 7-AVCA with MICE. The results showed that, cefixime has high purity (HPLC purity: 97%) and total yield 66% in the reaction time of 1.5 hours (less than 30 minutes with previous process).

Keywords: 7-AVCA; MICE; cefixime methyl ester; cefixime.

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