Abstract

BIOCHEMICAL STUDY ON THE EFFECT MURRAYA KOENIGII (CURRY) AND MORINGA OLEIFERA IN CARDIAC DYSFUNCTION IN DIABETIC RATS

Yakout A. El Senosi*, Omayma A. R. Abou Zaid, Afaf Desouky A.elmaged, EL Saeed E. Ahmed and Heba S. EL. Din Ebrahim*

ABSTRACT

In the present study, the biochemical effect of Murraya Koenigii (curry) and Moringa oleifera aquous extract on cardiac dysfunction in experimentally induced diabetes mellitus in rats by Streptozotocin (STZ) was evaluated. Sixty male albino rats weighting 150-200 g and divided into four equal groups of 15 rats each. Group 1 :(Control group): received normal diet only. Group 2 :( Diabetic rats group): rats received a single dose of Streptozotocin (STZ) (50- mg/kg-b.wt i.p). Group 3 :(Diabetic rats + Murraya Koenigii (curry) aquous extract of leaves at dose of 200mg/kg/ twice daily, orally for four weeks after diabetes induction. Group 4:(Diabetic rats+ Moringa oleifera aquous extract of leaves at dose of 200 mg/kg/ twice daily orally for four weeks after diabetes induction. Blood sample and tissues of heart, pancreas and liver were collected at the end of experiment for histopathological examination. The obtained results showed that, STZ-induced diabetic rats exhibited a significant increase in serum glucose, totalcholesterol, triglyceride (TG), LDL cholesterol, creatine kinase (CK), lactate dehydrogenase (LDH) and interleukin 6 (IL6) with marked decrease in insulin and HDL-cholesterol. Treatment with Murraya Koenigii (curry) and Moringa oleifera were able to mitigate diabetic abnormalities through decreasing serum glucose, totalcholesterol, triglyceride (TG), LDL cholesterol, creatine kinase (CK), lactate dehydrogenase (LDH) and interleukin 6 (IL6) and increasing insulin and HDL-cholesterol. These results suggest that Murraya Koenigii (curry) and Moringa oleifera have hypoglycemic effect, hypolipidemic and increasing insulin secretion. so, decreasing complication and protect heart in diabetic rats by improving biochemical blood parameters.

Keywords: Murraya Koenigii (curry), Moringa oleifera, STZ, Diabetes, glucose, insulin, lipid profile, CK, LDH, IL6.