Abstract

A REVIEW ON TEMPERATURE TRIGGERED OPTHALMIC INSITU GEL

Arun T. S.*, Subash Chandran and Dr. A. S. William Arputha Sundar

ABSTRACT

Eye is the most vital organ of the body. To achieve effective ocular therapy, an adequate amount of active ingredients must be delivered and maintain at the site of action within the eye. The anatomical structure and the protective physiological process of the eye exert a formidable defense against ophthalmic drug delivery, leads to poor precorneal drug loss results in poor ocular by availability and ultimately poor ocular therapy. The ‘in situ gel’ system has emerged as one of the best novel drug delivery systems; it helps for the sustained and controlled release of the drugs by its special characteristic feature of ‘Sol to Gel’ transition. In situ gelling system is a formulation that is in solution form before entering in to the body, but it will change to gel form under various physiological conditions. There are various polymers which under go in situ gel forming and potentially used for various routes of drug administration. There are several applications and advantages of in situ gelling system in today’s life. This review mainly focus on introduction to in situ gel, its mechanism, various polymers used and its applications.

Keywords: In situ gel, in situ gelling polymers, temperature sensitive.