Abstract

AUTOMATIC POTENTIOMETERIC DETERMINATION OF SOME THIRD GENERATION CEPHALOSPORIN'S ANTIBIOTICS

Elgendy Kh., Turkey A. and Fadel S.

ABSTRACT

A rapid potentiometeric method was suggested for determination of micro amounts of a number of third generation cephalosporin in pure as well as in commercial samples. The method based on oxidation of (cefoperazone, ceftazidime, cefotaxime, ceftriaxone) with iodate in acidic medium. An excess of iodate solution was added to different concentration samples of each drug in sulfuric acid medium of (pH= 2-3) with heating for few minutes, followed by boiling for another 5 minutes to expel iodine. The un reacted amount of iodated was determined potentiomery by back titration with Hg(II) using Agelectrode coupled with calomel electrode(SCE). A concentrations ranging of 0.2 to 12 m mol/liter of each drug were determined by this method were found to be sensitive and precise. The method was applied for the micro determination of the suggested drugs alone or in drug mixtures as in pure and in formulated samples.

Keywords: Potentiometric titration, cephlosporines, potassium iodate, back titration, pharmaceutical samples.