Abstract

SILICA NANOPARTICLES LOADED SODIUM SALICYLATE AND GINGER AS PROMISING HEPATOTOXICITY PROTECTIVE AGENTS IN EXPERIMENTAL RATS

Nadia A. Mohamed*, Zakaria El-Khayat and Rehab A. Mohamed

ABSTRACT

Ultrasound-assisted sol−gel method was used to prepare hollow structured poroussilica nanoemulsion loaded with sodium salicylate as a model drug. The work was extended to achieve the target of the current work via investigating the protective role this nanoemulsion model as anti-inflammatory drug or ginger for its antioxidant effect against cisplatin-induced hepatotoxicity in male albino rats. The results clarify that the nanoemulsion model was synthesized using ultrasonic assisted with small size and well stabilization as proved by TEM and DLS analysis. Additionally, Serum AST, ALT and δGT were increased after cisplatin injection with disorders in oxidative stress parameters and rising of serum HA, MMP-1, TIMP-1 and NF-κb levels. Also, histopathological changes of the liver tissues were observed. These changes back to normal by treatment with silica nanoparticles loaded sodium salicylate (Si-Sc-NPs), ginger or both. oil/water nanoemulsion of (Si-Sc NPs)and ginger showed a protective and promising preventive strategy against hepatotoxicity due to their antioxidant and anti-inflammatory effects and that offer a new approach in attenuating of drug induced hepatotoxicity.

Keywords: Silica nanoparticles coated sodium salicylate, Drug hepatotoxicity, cisplatin, liver, rats.