Abstract

ANTIMICROBIAL ACTIVITY OF LEAF EXTRACT AND GC-MS ANALYSIS OF HEXANE FRACTION FROM MEZONEURON BENTHAMIANUM BAILL (CAESALPINICEAE)

Morufu Adisa Ademoye*, Labunmi Lajide and Bodunde Joseph Owolabi

ABSTRACT

The antimicrobial activity of the leaf extract and the gc-ms analysis of the hexane fraction from the extract of Mezoneuron benthamianum were examined. The extract showed zone of inhibition of 21 mm against Escherichia coli, 18 mm against Shigella flexnerii, 11 mm against Salmonella thyphii and 10mm against Pseudomonas aeruginosa, Staphylococcus aureus and Candida albicans. The gc-ms analysis of the hexane fraction revealed the presence of twenty three compounds. Some of the compounds with reported activities are vitamin E 2.09 %, spathulenol 2.34 %, phytol 17.63 %, 9-Octadecyne 1.12 %, γ-sitosterol 4.73 %, squalene 2.17 %, Hexadecanoic acid methyl ester 19.50 % and linoleic acid ethyl ester 10.00 %. The research effort shows that the plant demonstrated antimicrobial activity which could be related to the individual or additive effect of its active compounds.

Keywords: Antimicrobial activity, GC-MS analysis, Mezoneuron benthamianum.