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World Journal of Pharmacy and
Pharmaceutical Sciences

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology

Impact Factor : 8.025

ICV : 84.65

WJPPS Citation

	All	Since 2019
Citation	5450	3969
h-index	23	20
i10-index	134	84

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WJPPS Rank with Index Copernicus Value 84.65 due to high reputation at International Level

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WJPPS: NOVEMBER ISSUE PUBLISHED

NOVEMBER 2024 Issue has been successfully launched on 1 NOVEMBER 2024.

Abstract

KINETICS AND MECHANISM OF OXIDATION OF AMITRIPTYLINE HYDROCHLORIDE DRUG BY CHLORAMINE-T IN ALKALINE BUFFER MEDIUM: A SPECTROPHOTOMETRIC APPROACH

Fathyah Omar Abdulsalam Imbarik and Asha Iyengar*

ABSTRACT

Kinetics of oxidation of amitriptyline hydrochloride drug (AMT) by chloramine-T (CAT) in alkaline buffer medium (9.3) at 306 K has been investigated spectrophotometrically at Î»max378 nm. The reaction showed first-order dependence on [CAT] and [AMT] o and inverse fractional-order dependence on [OH-] and [PTS]. Stoichiometry of the reaction was found to be 1:1 with respect to the substrate and oxidant respectively. The oxidation products were identified by spectral analysis. Variation of ionic strength had no effect on the rate. Addition of p-toluene sulphonamide (PTS) retarded the rate of the reaction. Activation parameters have been computed. Probable mechanism and the relevant rate law have been deduced for the observed kinetic results.

Keywords: Amitriptyline hydrochloride, CAT, oxidation-kinetics, alkaline medium.

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