![]() |
|||||||||||||
|
All | Since 2019 | |
Citation | 5450 | 3969 |
h-index | 23 | 20 |
i10-index | 134 | 84 |
KINETICS AND MECHANISM OF OXIDATION OF AMITRIPTYLINE HYDROCHLORIDE DRUG BY CHLORAMINE-T IN ALKALINE BUFFER MEDIUM: A SPECTROPHOTOMETRIC APPROACH
Fathyah Omar Abdulsalam Imbarik and Asha Iyengar*
ABSTRACT
Kinetics of oxidation of amitriptyline hydrochloride drug (AMT) by chloramine-T (CAT) in alkaline buffer medium (9.3) at 306 K has been investigated spectrophotometrically at λmax378 nm. The reaction showed first-order dependence on [CAT] and [AMT] o and inverse fractional-order dependence on [OH-] and [PTS]. Stoichiometry of the reaction was found to be 1:1 with respect to the substrate and oxidant respectively. The oxidation products were identified by spectral analysis. Variation of ionic strength had no effect on the rate. Addition of p-toluene sulphonamide (PTS) retarded the rate of the reaction. Activation parameters have been computed. Probable mechanism and the relevant rate law have been deduced for the observed kinetic results. Keywords: Amitriptyline hydrochloride, CAT, oxidation-kinetics, alkaline medium. [Download Article] [Download Certifiate] |