Abstract

SYNTHESIS AND ANTI INFLAMMATORY ACTIVITY OF 3-(2-4-METHYL-2-(2-NITROPHENYLAMINO)-6-(PIPERAZIN-1-YL METHYL) PYRIMIDIN-5-YL)-2H-CHROMEN-2-ONE

P. R. Logesh Kumar* and Dr. Girendra Gautam

ABSTRACT

The pyrimidine ring system has wide occurrence in nature as substituted and ring fused compounds and derivatives, including the nucleotides, thiamine (vitaminB1) and alloxan. It is also found in many synthetic compounds such as barbiturates and the HIV drug, zidovudine. Although pyrimidine derivatives such as uric acid and alloxan were known in the early 19th century, a laboratory synthesis of a pyrimidine was not carried out until 1879, when Grimaux reported the preparation of barbituric acid from urea and malonic acid in the presence of phosphorus oxychloride

Keywords: Pyrimidine, 2-nitrophenylamine, spectral analysis, anti inflammatory.