Abstract

ISOLATION OF STARCH FROM JACKFRUIT SEED AND EVALUATION OF ITS BINDING AND DISINTIGRATING PROPERTIES

Palla Srikanth*, A. Seetha Devi, P. Koteswari and Palla Sreelekha

ABSTRACT

In this study, jackfruit seed flour was prepared and starch was extracted using different extraction conditions such as (distilled water method and alkaline method). The results showed that distilled water method gave highest yield compared to alkali method. Starch identification tests were carried out on isolated material as confirmation tests. To evaluate the binding properties of seed starch, using paracetamol as model drug tablets were prepared by wet granulation method. Micromeritic properties for granules and powder mix gave good and passable flow properties. Post compression studies also gave good results i.e., obey the pharmacopoeial limits. The prepared tablets were evaluated for in vitro drug release studies and compared with the marketed tablets P-250apex. The r2 values of regression plots for First order and Zero order were considered for both the binding (F1, F2, F3) and disintegrating (S1, S2, S3) properties, r2 values for the First order was found to be more than Zero order. Hence it was confirmed that the drug release follows first order kinetics. Therefore the release rate in formulations depends on concentration or amount of drug incorporated. Compatibility studies were conducted by FTIR spectrometer and concluded that there was no interaction between seed starch and drug. And comparison between seed starch and commercial starch gave near peaks. The overall results showed that jackfruit seed might be used good source of starch as well as extracted starch could be used as binding agent and disintegrating agent in pharmaceutical formulations.

Keywords: Paracetamol, Jackfruit seed, Starch, Binding properties, Disintegrating properties.