Abstract

FORMULATION AND EVALUATION OF MATRIX DIFFUSION DRUG DELIVERY SYSTEM OF TABLETS CONTAINING KETOROLAC BY USING NATURAL POLYMERS

Asiya*, Madhan and Dr. M. Dhanalakshmi

ABSTRACT

In the present work, an attempt has been made to develop Matrix Diffusion Controlled Release Matrix tablets of Ketorolac by selecting different Types of polymers Aloes Powder, Gum copal, Gum dammar, Neem Resin Powder. All the formulations were prepared by direct compression method. The blend of all the formulations showed good flow properties such as angle of repose, bulk density, tapped density. The prepared tablets were shown good post compression parameters and they passed all the quality control evaluation parameters as per I.P limits. Among all the formulations F5 formulation showed maximum % drug release i.e., 98.39 % in 12 hours hence it is considered as optimized formulation F5 which contains Gum copal (30mg).

Keywords: Ketorolac, Aloes Powder, Gum copal, Gum dammar, Neem Resin, Controlled Release Matrix tablets.