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VALIDATED SPECTROPHOTOMETRIC QUANTITATION OF LEVOFLOXACIN IN BULK AND TABLET DOSAGE FORM
Pooja M.*, Sowmya H. G. and Jose Gnana Babu C.
ABSTRACT A novel, simple, accurate and precise Zero order derivative spectroscopic method was developed and validated for the estimation of Levofloxacin in bulk and Pharmaceutical dosage forms and has an absorption maximum at 293.6 nm in 0.1N Sulphuric acid. The Linearity was found to be in the concentration range of 5-30μg/ml and the correlation coefficient was found to be 0.999 and it has showed good linearity, reproducibility, precision in this concentration range. The regression equation was found to be Y = 0.019 X + 0.003. The % recovery values were found to be within 99.14 -100.16 % showed that the method was accurate. The LOD and LOQ were found to be 0.3041 and 0.9123μg/ml, respectively. The % RSD values were less than 2. The method has been validated according to ICH guidelines for linearity, accuracy, precision, robustness, ruggedness. Limit of detection and limit of quantitation. Proposed method was successfully applied for the quantitative estimation of Levofloxacin in bulk and pharmaceutical dosage form. Keywords: Levofloxacin, Zero order derivative Spectroscopy, 0.1N Sulphuric acid, Linearity, Precision, Reproducibility, and Accuracy. [Download Article] [Download Certifiate] |