Abstract

FORMULATION AND EVALUATION OF ALOE VERA BASED HYDROGEL FOR TREATMENT OF BURNS

Shital S. Patil*, Prashant S. Malpure, Yashpal M. More, Priti P. Nikam and Santosh S. Surana

ABSTRACT

Mupirocin is an antibacterial drug, has been used in the treatment of wounds, topical infection. This study was conducted to develop a hydrogel formulation of mupirocin using two types of gelling agents xanthan gum and gelatin. The gels were evaluated for physical appearance, rheological behavior, drug release and stability. The drug release of all formulations study by using Franz diffusion apparatus. All gels showed acceptable physical properties concerning color, homogeneity, consistency, spreadability and pH value. Among all the gel formulations, F9 showed superior drug release. Stability studies showed that the physical appearance, rheological properties, and drug release remained unchanged upon storage for two months at ambient conditions.

Keywords: Mupirocin topical hydrogel; xanthan gum; gelatin; drug release.