Abstract

RECENT ADVANCES OF SOLID LIPID NANOPARTICLES: A REVIEW

U. Sahul Hameed Niyaz* and K. Elango

ABSTRACT

Most of the active pharmaceutical ingredients (APIs) under development are poorly water soluble and have poor bioavailability. Nanotechnology is an approach to overcome the challenges of conventional drug delivery systems. Solid Lipid nanoparticles show interesting features concerning therapeutic purposes. The main advantage is that they are prepared with physiologically well-tolerated lipids. Solid Lipid Nanoparticles (SLNs) as novel lipid based nanocarriers with size range between 10 to 1000nm. SLNs were introduced to overcome problems of polymeric nanoparticles. By putting forward physiological safe lipids in place of polymers to prepare lipid nanoparticles, a novel formulation technique came into light. An approach undertaken here is to focus on various production methods for preparation of SLNs, wide pharmaceutical applications of SLNs in drug delivery are explored.

Keywords: Solid lipid nanoparticles; Colloidal delivery system; Oral Bioavilability; Water Insoluble Drugs; Preparation; Characterisation.