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TECHNIQUE TO ENHANCE THE BIOAVAILABILITY AND SOLUBILITY FOR POORLY WATER SOLUBLE DRUGS BY USING: SOLID DISPERSION
Mohd. Asad Farooqui*, Dilip Km. Patel and Roohi Kesharwani
ABSTRACT
Solid dispersions of poorly water-soluble drugs with water-soluble carriers have been reduced the incidence of these problems and enhanced dissolution. The focus of this review article on advantages, disadvantages and the method of preparation, and characterization of the solid dispersion. The solubility issues complicating the delivery of these new drugs also affect the delivery of many existing drugs. The various techniques are available for enhancement of solubility. Solid dispersion is one of the most promising approaches for solubility enhancement. Currently only 8% of new drug candidates have both high solubility and permeability. More than 60% of potential drug products suffer from poor water solubility. Keywords: Solubility, Solid Dispersions, Carrier, Bioavailability Hydrophilic, Fusion method. [Download Article] [Download Certifiate] |