Abstract

SYNTHESIS, STRUCTURAL CHARACTERIZATION AND ANTIBACTERIAL EVALUATION OF SOME NEW 2-PYRAZOLINE DERIVATIVES

*Abdul-Wahhab J. Al-Hamdany and Sevgi S. Arslan

ABSTRACT

The title compounds were synthesized by condensation of ethyl acetoacetate, urea and substituted benzaldehydes resulting pyrimidinones and in treating with hydrazine hydrate gave pyrimidinone hyrazides which by condensation with 2- nephthyl chalcones by Micheal addition (1,4) afforded the titled compounds 6- Methyl-5-(5-2-naphthyl)-3-aryl-2,3-dihydro-1-H-pyrazole-1-carbonyl-4-aryl- 3,4-dihydro pyrimidin-2-(1H)-ones or pyrazoline derivatives (1-35). The spectral data and some physical properties were used to support the structure of new products. (UV, IR, 1H-NMR, 13C-NMR), the suggested mechanism of the product formation was supported by theoretical calculations of AM1 modeling model. The antibacterial activity of some prepared compounds were tested through its inhibition effects on two kinds of bacteria.

Keywords: 2-naphthyl chalcone, pyrimidinones, 2-pyrazolines, anti-bacterial activity.