Abstract

MICROWAVE SYNTHESIS AND PHARMACOLOGICAL IMPORTANCE OF 1,2,4- TRIAZOLE DERIVATIVES – A REVIEW

Mamta Khatak*, Parbhakar Kumar Verma

ABSTRACT

In the last few decades, the chemistry of 1,2,4-triazoles and their fused heterocyclic derivatives has received considerable attention owing to their synthetic and effective biological activities such as antinflammatory, CNS stimulants sedatives, antianxiety, antimicrobial agents and antimycotic activity such as fluconazole, intraconazole, voriconazole. Also, there are known drugs in market containing the 1,2,4-triazole group e.g. Triazolam, Alprazolam, Etizolam and Furacylin. Present antitubercular drugs are more toxic and multiple drug therapy is required. So it is important to find out the analogues with good antitubercular activity. Microwave heating has attracted the attention of investigators in synthesis of drugs to shorten the length of reactions significantly, to increase their selectivity, and to increase the product yields, which is particularly important in the case of high-temperature processes that take a long time. This review includes the Microwave synthesis of 1,2,4- triazoles and its reported derivatives.

Keywords: 1,2,4-triazole , Antitubercular , Microwave.