Abstract

PHYSICAL CHARACTERISTICS OF RESERVOIR TYPE PATCH USING NANOSTRUCTURED LIPID CARRIERS (NLC) AS DRUG RESERVOIR, HPMC 606 AS RATE CONTROLLING MEMBRANE AND MELOXICAM AS DRUG MODEL

*Esti Hendradi, Asri Darmawati, Adek Bela Anggraeni

ABSTRACT

The purpose of this research work was to create a meloxicam patch transdermal drug delivery system using Nanostructured Lipid Carriers (NLC) as drug reservoir and Hydroxy Propyl Methyl Cellulose (HPMC) as rate controlling membrane. Meloxicam, ananti-inflammatorynon-steroidal drugs, was used as drug model. The NLC was done by using high-shear homogenization method. In the formulation of NLC meloxicam using monostearin and alpha-tocopherol as lipid matrix. The transdermal patches of meloxicam were prepared by using different percentages of rate controlling membrane. NLC Meloxicam was dispersed into 1 ml rate controlling solution and spread over the backing layer followed by drying at room temperature.The patches were evaluated for physical appearance, weight variation, moisture content, drug content uniformity and morphology. The patches demonstrated satisfactory characteristics with minimum weight variation among the patches that lead to give uniformity in the drug content.

Keywords: patch, meloxicam, NLC, transdermal.