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World Journal of Pharmacy and
Pharmaceutical Sciences

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology

Impact Factor : 8.025

ICV : 84.65

WJPPS Citation

	All	Since 2019
Citation	5450	3969
h-index	23	20
i10-index	134	84

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WJPPS Rank with Index Copernicus Value 84.65 due to high reputation at International Level

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WJPPS: NOVEMBER ISSUE PUBLISHED

NOVEMBER 2024 Issue has been successfully launched on 1 NOVEMBER 2024.

Abstract

NEUROPHARMACOLOGICAL SCREENINGS OF HYDROALCOHOLIC FRACTIONS OF URENA LOBATA L.

Md. Torequl Islam*, Rivelilson Mendes de Freitas, George Laylson da Silva Oliveira ,Bishwajit Guha

ABSTRACT

Effects of hydro-methanolic fractions of Urena lobata L. on some neuropharmacological activities were studied in Swiss mice. The methanolic fraction in dose (400 mg/kg) was found to produce a profound decrease in exploratory activity and number of swings. Methanol fraction also showed a marked sedative effect as evidenced by a significant reduction in gross behaviour and potentiation of pentobarbitone-induced sleeping time. It produced onset of sleep by 8.2Â±0.82 minutes when compared to the standard, diazepam by 2.4Â±0.57 minutes. The chloroform and hydro-methanol fractions also produced significant sedative activities. The totality of these effects showed that the extracts possess depressant action on the central nervous system.

Keywords: Urena lobata L., Malvaceae, neuropharmacology, swing test.

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