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SYNTHESIS AND BIOLOGICAL POTENTIAL OF 1, 3- OXAZINE AND 1, 4-OXAZINE DERIVATIVES- A REVIEW
Nicy Rose P. * and Meena Chandran Krishnakumar K.
ABSTRACT
Oxazine derivatives are an important class of heterocycles, which are useful in the field of medicinal and pharmaceutical chemistry and have been reported to exhibit variety of biological activities. Oxazine derivatives are synthesized on reaction of chalcone with thiourea in the presence of alcoholic NaOH. Oxazines have been reported to possess activities such as antibacterial, antifungal, antitubercular, analgesic, anti-inflammatory etc. The present review aims to give an outline of different methods involved in the synthesis and biological activities of 1,3-Oxazines and 1,4- Oxazines. Keywords: 1, 3-Oxazines, 1,4- Oxazines. [Download Article] [Download Certifiate] |