Abstract

CHEMICAL SCIENCE SYNTHESIS AND BIOLOGICAL STUDY OF SOME NEW THIAZOLIDINON DERIVATIVES

*Vandana B. Patel and M. K. Thakor

ABSTRACT

Fused heterocyclic compounds (3a-h) namely N-(3,5-diphenyl-3,3a-dihydro-2H-pyrazolo[3,4-d] thiazol-6(5H)-yl)-2-(5-(2-hydroxyphenyl)-2-thioxo-1,3,4-oxadiazol-3(2H)-yl) propanamide were prepared and characterized. First Oxadiazolo-thiazolidinones (1a-h) on condensation with benzaldehyde give the arylidine derivatives (2a-h). Such compounds 2a-h on reaction with hydrazine hydrate give the title compounds i.e. 3a-h. All the compounds were screened for their antimicrobial activity.

Keywords: Oxadiazolo-thiazolidinones, arylidine, 1,3,4-oxadiazol, hydrazine hydrate, antibacterial and antifungal activities.