![]() |
|||||||||||||
|
All | Since 2019 | |
Citation | 5450 | 3969 |
h-index | 23 | 20 |
i10-index | 134 | 84 |
PREPARATION AND EVALUATION OF LOSARTAN POTASSIUM MUCOADHESIVE MICROSPHERES
Nethaji Ramalingam*, Binulal C., Manikandan Palanivelu and Babu Ganesan
ABSTRACT The present study deals with Losartan potassium Mucoadhesive microspheres formulation using sodium alginate, carbopol 934 and sodium carboxy methyl cellulose by ionic gelation technique with an aim to prolonged and sustained the drug release with an improve the bioavailability. Ten formulations were prepared by using different in drug to polymer ratios, and evaluated the relevant parameters. The percentage yield of all the formulations is found between 64.61% to 88.44%. The surface morphology of the formulated microspheres was characterized by SEM and it was discrete, spherical in shape and showed free flowing properties. The mean particle size of the microspheres is range between 134.4μm to 197.6μm. Among all the formulations, LP6 showed high drug entrapment efficiency (65.76%), highest percentage swelling index (84.76%) and lowest percentage moisture loss (7.68%). The in-vitro wash-off test indicated that the microspheres were shown good mucoadhesive properties. The in-vitro drug release studies revealed that LP6 formulation shown sustained effect and it was found to be 77.91% at the end of dissolution studies. The mechanism of drug release was also evaluated using the linear regression coefficient according to the various kinetic models which to found goodness of fit. Stability studies of selected formulations showed good results. It could be conclude that all formulated microspheres were shown satisfactory results and suitable for the gastro retentive drug delivery system (GRDDS) for potential therapeutic uses. Keywords: Losartan Potassium, Mucoadhesive Microspheres, Carbopol 934, Sodium carboxy methyl cellulose, in-vitro evaluation, Stability studies. [Download Article] [Download Certifiate] |