Abstract

DESIGN & DEVELOPMENT OF FAST DISSOLVING ORAL FILMS OF KETOPROFEN

Srikrishna T.*, Dr. M. Gobinath, Bharath P., Y. Nagarjuna Reddy, G. Rakesh, R. Jagadeesh Sairam, Md. Thouseef

ABSTRACT

Fast dissolving oral films can be defined as a dosage form, which when placed in the oral cavity it will rapidly disintegrate and dissolves to release the medication for oral mucosal absorption. Ketoprofen is Non-steroidal Anti-inflammatory agent and Analgesic properties and can be used in low dose as analgesic and anti-inflammatory agent in Rheumatoid Arthritis. This study aims to formulate Ketoprofen as oral dissolving film, to improve the effective relief of pain with severe Rheumatoid Arthritis with little or no adverse effects. In this study 8 formulations were prepared with natural and synthetic film formers using solvent casting method and the effect of different formulation variables on the physical and mechanical properties of the prepared films, besides to the drug release behavior was evaluated. It was found that, the prepared oral film of Ketoprofen that contains Pectin showed the fastest disintegration time (19sec) among the other investigated polymers. The drug release rates were also observed, F3 formulation showed (Pectin) 97.30% drug release within 4 minutes with satisfactory mechanical properties. The overall results suggested that the prepared Ketoprofen fast dissolving oral films can be used as an attractive and alternative to the commercial available immediate release and conventional tablets resulting improved patient adherence.

Keywords: Fast dissolving oral films, Ketoprofen, Rheumatoid Arthritis, Non-steroidal Anti-inflammatory agent, solvent casting method.