Abstract

DEVELOPMENT OF EXTENDED RELEASE DOSAGE FORM OF NSAIDS USED IN COLON TARGETED DRUG DELIVERY

P. Raman Kumar*, P. Venkateswara Rao, U. Pavani1, U. Baji, R. Padmavathi

ABSTRACT

The present research concerns formulate an extended release matrix tablet of Aceclofenac based on hydrophobic matrix using ethyl cellulose polymer. Formulations will be prepared by using different diluents like micro crystalline cellulose, lactose, dicalcium phosphate. Effect of binder concentration in Formulations will be determined by increasing binder concentration. Four batches (F1-F4) of extended release tablets were made using various grade of ethyl cellulose in their maximum and minimum concentrations. Various effects of different grades on the drug release were noted. Formulation of Aceclofenac was formed by different techniques like direct compression and wet granulations having 100mg strength. Results show that when ethylcellulose was used alone in a same concentration in batch F1 and F2 were prepared by direct compression method and batch F3 and F4 were prepared by wet granulation method respectively. The batch F3 and F4 give the best evaluation parameter like weight variation, flow property, friability and hardness etc. as comparison to F1 and F2. The wet granulation technique is the best suitable technique for extended release dosage forms as comparison to direct compression. The F3 and F4 batch show less release as comparison to F1 and F2, It means this technique is best for extended release. When the percentage of microcrystalline cellulose was increased in batch F4 as comparison to other batches, the tablet shows the best extended release than the other batches.

Keywords: Aceclofenac, Extended Release, Dry Granulation, Wet Granulation, Ethyl cellulose grades and Micro crystalline cellulose.