Abstract

SYNTHESIS, CHARECTERIZATION AND BIOLOGICAL EVALUATION OF POTENTIAL METALLO-?-LACTAMASE INHIBITORS

Dr. P. Manichandrika*, V. Rashmita, P. Priyanka, Sai Prathibha Panthulu, M. Punam, P. Sahithi

ABSTRACT

β – lactam anti-infective agents are the most commonly used antibacterial drug and developing resistance to these medications is a worry. Metallo-β-lactamases are a various set of enzymes that catalyze the hydrolysis of a broad range of β-lactam drugs including carbapenems. This decent variety is reflected in the perception that the enzyme mechanism varies in light of whether may be a couple zincs are bound in the active site which, in turn, is reliant on the subclass of β-lactamase. The spread of the genes encoding these enzymes among Gram-negative bacteria has made them a vital reason for resistance. Thereare right now no clinically accessible inhibitors to inhibit metallo-β-lactamase activity. The reason for this investigation is to make various types of MBL inhibitors, and test for their exercises on various microorganism. In this examination our point is to combination some more up to date 2-substituted-3-mercaptopropanoic acids subordinates as metallo β – lactamase inhibitor.

Keywords: ?-lactamase; antibiotic resistance; carbapenem; zinc metallo-enzyme.