Abstract

A REVIEW ON MUCOADHESIVE BUCCAL DRUG DELIVERY SYSTEM

Bharati D. Aher*, Dattatraya M. Shinkar, Parag D. Kothawade and Avish D. Maru

ABSTRACT

Buccal drug delivery is the most innovative delivery system which releases the drug to buccal mucosa by avoiding first pass metabolism in the liver and pre systemic elimination in the gastrointestinal tract. The buccal mucosa has a rich blood supply and local environment of the mucosa can be controlled by an exact dosage form in order to optimize drug dissolution and permeation. This article gives a brief idea about bioadhesive delivery systems surfaces that are covered by mucus. Techniques thatare frequently used to evaluate the mucoadhesive drug delivery systems are discussed. Mucoadhesion can be defined as a state in which two components, of which one isof biological origin are held together for extended periods of time by the help of interfacial forces. Mucoadhesion is a complex phenomenon which involves wetting, adsorption and interpenetration of polymer chains. The concept of mucoadhesion in drug delivery was introduced in the early 1980s. There after, several researchers have focused on the investigations of the interfacial phenomena of mucoadhesion with the mucus. Mucoadhesive drug delivery systems is one of the most important for various chronic disease. The aim of this study was to review the mechanisms and theories involved in mucoadhesion.

Keywords: Mucoadhesion, Mechanism of mucoadhesion, Theorys of mucoadhesion.