Abstract

A REVIEW ON DRUG SOLUBILITY: IMPORTANCE AND ENHANCEMENT TECHNIQUES

Umesh Pere*, DR. K. S. Salunkhe, Dr. M. J. Chavan, Dr. R. S. Shendge, Amit Asti and Harshada Wagh

ABSTRACT

Traditionally, nearly 40% of the new chemical entities (NCEs) identified by pharmaceutical industry screening programs have failed to be developed due to poor water solubility, which makes their formulation difficult or even impossible to come into the regular market. Solubility is one of the important way to achieve the desired concentration of drug into the systemic circulation for its pharmacological response and also most of the drug are weekly acidic and weakly basic with poorly aqueous solubility. The oral route of administration is the most preferred and widely accepted route of delivery due to ease of ingestion for many drugs, However these drugs with slow dissolution rate and low solubility in an aqueous media shows the incomplete absorption leading to low bioavailability when Orally administered poorly soluble drugs often require high doses in order to reach therapeutic plasma concentration of oral concentration because of which increase in the side effects for certain drugs. Pharmaceutical drugs falling under the Biopharmaceutical Classification System (BCS) class ӀӀ and IV are the main emphasis of this review as these drugs are of low solubility. Here we discussed about traditional techniques, novel drug delivery technologies, solid dispersion techniques and to enhance the solubility as well as the bioavailability of low soluble drugs.

Keywords: Bioavailability, New chemical entities, Solubility, Absorption, Biopharmaceutical Classification System, Drug delivery technologies.