Abstract

IN VITRO ANTI-HYPERLIPIDEMIC ACTIVITY OF SEED EXTRACT OF SYZYGIUM CUMINI LINN

P. Divya Bhargavi*, Dr. B. Duraiswamy and A. Vasudha

ABSTRACT

Hyperlipidemia is a disorder of lipid metabolism which is major risk of coronary heart disease. Coronary heart disease, stroke, atherosclerosis and hyperlipidemia are the primary causes of death. The elevation of serum total cholesterol and low density lipoprotein (LDL) cholesterol has been reported as a primary risk factor for cardiovascular disease. Anti-hyperlipidemic drugs are extensively used as prophylactic agents to prevent such atherosclerosis induced disorders. These drugs are not free from adverse effects but herbal medicines have lipid lowering and antioxidant activities without any side effects. More than 70 medicinal plants have been documented to have significant anti-hyperlipidemic action. During the last decade, an increase in the use of medicinal plants has been observed in metropolitan areas of developed countries. The plant Syzygium cumini Linn. (Myrtaceae) commonly called as Jamun, black plum or Indian black berry. Entire plant of Syzygium cumini such as seed, fruit, leaves, flower, bark used in folk medicine. The plant contains anthocyanins, glucoside, ellagic acid, isoquercetin, kaempferol, and myricetin as its chief active constituents. These active constituents impart multiple pharmacological activities to the plant which includes antihyperlipidemic, antidiabetic, anticancer, antioxidant, antibacterial, antifungal and antidiarrheal activity. The purpose of the present investigation is to evaluate the alcoholic and hydroalcoholic extracts of Syzygium cumini Linn seed for in-vitro anti-oxidant and anti-hyperlipidemic activity on 3T3-L1 cell line.

Keywords: Syzygium cumini, cholesterol, triglycerides, 3T3-L1 cell line, Adipogenesis, Oil Red O stain.