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FORMULATON AND EVALUATION OF FILM FORMING GEL OF DICLOFENAC DIETHYLAMINE
J. Saravanan*, K. Elango, S. Daisy Chellakumari and K. Arulkumar
ABSTRACT Objective: The present aim of the study was to formulate and evaluate film forming gel of diclofenac diethylamine for sustained release of the drug. Methods: The gel was formulated using hydroxyl propyl methyl cellulose and polyvinyl pyrrolidine as gelling agents and various Eudragit polymers as film forming agent. The physical and chemical compatibility of the ingredients were studied using FT-IR spectroscopy and the results reveal the compatibility of the ingredients with each other. The formulated gel was subjected to rheological studies, characterization of the film and invitro drug release studies. Results: The formulation F1 shown considerably better characteristics than other formulations and subjected to invivo anti inflammatory studies. The results of the invitro and invivo studies were compared with that ofthe marketed gel. Conclusion: The optimized formulation shows a sustained release of the drug, better characteristics of the film and the same efficacy as that of the marketed formulation. Keywords: Film forming gel, Hydroxy propyl methyl cellulose, Eudragit, Diclfenac diethylamine. [Download Article] [Download Certifiate] |