![]() |
|||||||||||||
|
All | Since 2019 | |
Citation | 5450 | 3969 |
h-index | 23 | 20 |
i10-index | 134 | 84 |
FORMULATION AND EVALUATION OF ATORVASTATIN SOLID DISPERSIONS AND THEIR TABLET FORMULATION FOR ENHANCED BIOAVAILABILITY
Navid Reza*, Sheeba F.R., Dr. Sheeba, Dr. Shivakumar S., Dr. Kulkarni and Dr. Samira B.
ABSTRACT The main purpose of the present study is to increase the solubility of the Atorvastatin calcium which is giving the result of enhancement of bioavailability. In drug therapy bioavailability of the drug is so important and one of the major reason that making it less is the solubility. So many of drugs are having high molecular weight and high lipophilicity which indicate the low aqueous solubility. At present study, solubility enhancement is the challenge in formulation and development of the Atorvastatin calcium. One of the way to increase the bioavailability of drugs is solid dispersion, in present study solid dispersion of atorvastatin calcium was carried out with the use of three different hydrophilic carrier bye the solvent evaporation method. PEG 6000, Mannitol and Urea were used as carrier in ratio of 1:1, 1:2, 1:3, 1:4 and 1:5 by solvent evaporation method. After formulation, tablets were evaluated for polymer interaction, drug content, drug release and etc. All the formulations was within the Pharmacopoeial limit and also by referring to the result of evaluation, it showed all the formulations increased the drug release. The formulation F5 containing the PEG 6000 was showed the best result to enhance drug release and increase the solubility of atorvastatin calcium. The other carriers which were used also increased the solubility but the urea is showed the better result than mannitol. Keywords: Atorvastatin calcium, PEG 6000, Mannitol, Urea, Solid dispersion. [Download Article] [Download Certifiate] |