Abstract

FORMULATION AND EVALUATION OF TOPICAL GEL DELIVERY OF LORNOXICAM

Dharmendra Singh*, Anupam Kr. Sachan and Sunil Kumar

ABSTRACT

The aim of the present research work is to prepare and evaluate topical hydrogel of lornoxicam using different gelling agent for the treatment of inflammation. Lornoxicam is a highly selective cyclooxigenase-1 & cyclooxigenase-2 inhibitor used in the treatment of inflammation, pain and edema, rheumatoid arthritis and so on. Topical gel of Lornoxicam was formulated using triethanolamine (5%) as solvent, carbopol 934p as gelling polymer and various penetration enhancers. Formulated gel was evaluated with respect to different physiochemical parameters such as pH, viscosity, spreadability, gel strength. The in-vitro drug release rate of gel was evaluated using Franz diffusion cell with phosphate buffer 7.4 as the receptor medium. Stability studies carried out at different temperatures and humidity did not show any significant change in drug content, % CDR, viscosities and other parameters at the end of 12 weeks indicating that all the formulations were stable. It was concluded that Physiochemiclly stable and non-irritant Lornoxicam gel was formulated and the drug release increased with increase in concentration of penetration enhancer which is suitable for topical application.

Keywords: Lornoxicam, hydrogel, Penetration enhancers, in-vitro, penetration enhancer, inflammation.