Abstract

SELF-EMULSIFYING DRUG DELIVERY SYSTEM: A REVIEW

Suresh Chandra Pandey*, Rajveer Kaur, Gangadharapp H.V., Sachin J.

ABSTRACT

Purpose: The oral delivery of poorly water soluble drug can be prepared by SEDDS. The major advantages of this approach overcome the primary rate limiting step of drug dissolution in GIT. Sometime the drug may precipitate out of solution when the formulation dispersion in the GIT, mainly when hydrophilic solvent in used. This problem can be overcome by dissolving the drug in the liqid vehicle there is less potential for precipitation on dilution in the GIT.[18] Mehtods: Solid SEDDS were developed mainly by  Spray drying,  Spray cooling,  Solid carriers,  Melt extrusion,  Dry emulsion,  Melt Granulation  Supercritical Fluid Based Method  Solid Lipid Nanoparticles andNanostructured Lipid Carriers  Capsule Filling With Liquid and Semisolids Self Emulsifying Formulations  Solid dispersion etc. Conclusions: By using SEDDS we can Improvement in solubility & Bioavailability and we can use SEDDS for Herbal Drugs and Traditional Medicine. Results:  Improvement in solubility & Bioavailability  Protection against Biodegradation  SEDDS for Herbal Drugs and Traditional Medicine.

Keywords: Self-emulsifying drug delivery systems, lipophilic drugs and oral delivery.