Abstract

INSIGHTS INTO THE MOLECULAR COMPLEXITY OF PARKINSON’S DISEASE PATHOLOGY

Mahalakshmi A. M.*, Bipul Ray and Abid Bhat

ABSTRACT

Parkinson's disease (PD) is a progressive neurodegenerative motor disorder that results due the death of dopaminergic neurons in the substantia nigra. The complicated interplay of genetic and environmental factors affecting numerous fundamental cellular processes is viewed as primary cause for PD. Oxidative stress resulting from mitochondrial dysfunction, auto-oxidation, neuroinflammation, apoptosis and excessive iron accumulation in the substantia nigra pars compacta are the major cellular insults that result in the PD. In this article the role of this factors are discussed.

Keywords: Parkinson?s disease, neuroinflammation, apoptosis.