Abstract

CYCLOPHOSPHAMIDE: A COMPREHENSIVE REVIEW AS AN ANTICANCER

*Rashmi Wani, Shivaji Sumbhe, Akanksha Singh and Bhagyashree

ABSTRACT

Cyclophosphamide (CP), also known as Cytophosphane among other, is a medication used as chemotherapy and to suppress the immune system. Cyclophosphamide is classified as Alkylating agent are most active in the resting phase of the cell. These drugs are cell-cycle non specific. Cyclophosphamide is used to treat several forms of cancer including leukemias, lymphomas and breast cancer. and autoimmune diseases. Due to its toxicity, it is replaced as soon as possible by less toxic drugs. It is used to treat a certain type of kidney disease in children after other treatments have not worked. Cyclophosphamide therapy is associated with minor transient serum enzyme elevations and has been linked to rare cases of acute liver injury. In addition, when given in high doses as a part of a myeloablative therapy, Cyclophosphamide can cause acute sinusoidal obstruction syndrome. Cyclophosphamide is used alone or in combination with other medications to treat Hodgkin's lymphoma and non-Hodgkin's lymphoma, cutaneous T-cell lymphoma, Multiple myeloma and certain types of leukemia including chronic lymphocytic leukemia (CLL), chronic myelogenous leukemia (CML), acute myeloid leukemia (AML, ANLL), and acute lymphoblastic leukemia (ALL). It is also used to treat retinoblastoma (cancer in the eye), neuroblastoma (a cancer that begins in nerve cells and occurs mainly in children), ovarian cancer (cancer that begins in the female reproductive organs where eggs are formed), and breast cancer. Cyclophosphamide is also used to treat nephrotic syndrome.

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