Abstract

SKIN PENETRATION ENHANCEMENT IN NOVEL DRUG DELIVERY SYSTEM

Nazneen Ansari, Ravi Bharti, N. Syed Abdul Kader, Naresh Mandavi, Shekhar Verma, Chanchal Deep Kaur, Gyanesh Kumar Sahu and Harish Sharma*

ABSTRACT

The skin provides an effective barrier to protect the body from the penetration of molecules and micro-organisms in the external environment, and from excessive loss of water to maintain homeostasis. The main skin barrier resides in the stratum corneum due to its exclusive structure of layers of flattened corneocytes surrounded by lipid bilayers composed largely of ceramides. In recent years, the focus of pharmaceutical research is progressively shifting to the development of drug delivery systems rather than finding newer chemical entities for an all-round improvement in drug therapy. Multiferous materials and principles have been employed to generate a wide variety of carrier classes such as polymer-based particulate systems (microspheres, microcapsules, nanoparticles, and transdermal patches) and rigid, semi-rigid and vescicular lipoidal colloid drug delivery carriers (liposomes, niosomes, microemulsions, micelles). Novel drug delivery systems (NDDS) are particulate or vesicular dosage form in nanometer size range. NDDS are essentially required for effective transportation of loaded drug across the skin barriers. Nanotechnology defined as a tiny science. Design, characterization, production, categorization, and applications of structures, devices and systems by controlling shape and size at nanometer scale is refers to nanotechnology. From nanotechnology we can achieve better therapeutic action, enhanced bioavailability and better patient compliance. The present review focuses on the advantages of techniques which improves therapeutic efficacy through enhanced retention of nanocarrier.

Keywords: Skin Permeations, Novel Drug Delivery System (NDDS), Nanoparticles, Startum Corneum (SC), Skin Barriers.