Abstract

A BRIEF REVIEW ON PYRAZOLE DERIVATIVES POSSESING VARIOUSPHARMACOLOGICAL AND BIOLOGICAL EVALUATION

Sumathy Arunachalam*, Dr. N. L. Gowrishankar, Ankhitha Krishnan, Meenu Prakash, Muhsin T., Naseena U. and Poornima G.

ABSTRACT

ABSTRACT The aim of this review is to provide an overview of diverse pharmacological activities of pyrazole moiety. Pyrazole are well known and important nitrogen containing 5-membered heterocyclic compounds and various methods have been worked out for their synthesis. Pyrazole chemically known as 1, 2-diazolehas become a popular topic due to its manifold uses. Numerous pyrazole derivatives have been found to possess a broad spectrum of biological activities, which stimulated the research activity in this field. Pyrazoles and its derivatives represent one of the most active classes of compounds,which possess widerange of biological activities like anti-bacterial, anti-convulsant, analgesic, anti-microbial, anti inflammatory, anti diabetic, sedative anti-rheumatic, anticancer, and anti-tubercular activities. The purpose of this review was to collate literature work reported by researchers on pyrazole for their various pharmacological activities and also reported recent efforts made on this moiety.

Keywords: Anti-tubercular, anti-inflammatory, analgesic, anticonvulsant, anti microbial, anthelmintic, antioxidant, anti-inflammatory, antihypertensive and antiviral.