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World Journal of Pharmacy and
Pharmaceutical Sciences

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology

Impact Factor : 8.025

ICV : 84.65

WJPPS Citation

	All	Since 2019
Citation	5450	3969
h-index	23	20
i10-index	134	84

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WJPPS introducing updated version of OSTS (online submission and tracking system), which have dedicated control panel for both author and reviewer. Using this control panel author can submit manuscript

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WJPPS Impact Factor has been Increased to 8.025 for Year 2024.

WJPPS Rank with Index Copernicus Value 84.65 due to high reputation at International Level

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WJPPS is indexed in Scope Database based on the recommendation of the Content Selection Committee (CSC).

WJPPS: NOVEMBER ISSUE PUBLISHED

NOVEMBER 2024 Issue has been successfully launched on 1 NOVEMBER 2024.

Abstract

EVALUATION OF HEPATOPROTECTIVE ACTIVITY OF POLYHERBAL FORMULATION AGAINST ETHANOL INDUCED HEPATOTOXICITY IN RATS

B. Sreshta* and S. Ravindra Babu

ABSTRACT

The objective of the present study was to assess the hepatoprotective effect of polyherbal formulation(PHF) in ethanol induced hepatotoxicity in rats. Hepatoprotective activity of the PHF containing two indigenous medicinal plant extracts Tinospora cordifolia and Curculigo orchioides, was screened against ethanol induced hepatotoxicity in rats. PHF was evaluated by measuring levels of serum marker enzymes like SGOT, SGPT, albumin, creatinine and total protein. The histological studies were also studied to support the biochemical parameters. Silymarin was used as standard drug. Administration of ethanol shows significant morphological, biochemical and histopathological deteriorations in the liver of experimental animals. Administration of PHF (200 and 400 mg/kg p.o.) significantly inhibited(p

Keywords: Poly herbal formulation, Hepatotoxicity, Ethanol, CCl4, Tinospora cordifolia, Curculigo orchioides.

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