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Abstract

SPECTROPHOTOMETRIC ESTIMATION OF TOFISOPAM IN BULK DRUG AND PHARMACEUTICAL FORMULATIONS

Manzoor Ahmed, Amreen Kousar*, A. Satishkumar Shetty and G. Narayana Murthy

ABSTRACT

A simple, accurate and sensitive method for estimation of Tofisopam in bulk drug and pharmaceutical dosage form has been developed. The method employs zero order derivative spectroscopy. Estimation of Tofisopam was done in zero order derivative at 310 nm and obeyed Beer’s law in the range of 5-25μg/ml. The results of analysis were validated statistically as per ICH guidelines and recovery studies showed satisfactory results. Thus the method is accurate and reproducible and can be employed for routine analysis of Tofisopam in bulk drug and pharmaceutical dosage forms.

Keywords: UV Spectrophotometry, Tofisopam.


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