Abstract

DOSE DEPENDENT ANTI-DEPRESSANT ACTIVITY OF METHANOLIC EXTRACT OF MOMORDICA CHARANTIA SEEDS

D. Anusha*, K. Sravani, K. Sairani, K. Pravalika and K. Madhuri

ABSTRACT

Omordica charantia (M.charantia) seeds has supposed to have an antidepressant activity by methanolic extract. Objective: We investigated the anti-depressant effect of M. charantia methanolic seed extracts (MEMC) on anti-depressant activity in Wister rats. Materials And Methods: Momordica charantia was purchased from market. Seeds were shade dried and pulverized in blender. The pulverized extract was mounted on soxhlet extractor using methanol as solvent. The extract was examined for photochemical screening. The residue obtained after extract was examined for forced swimming test for studying anti-depressant activity using Albino Wister rats.[1] Conclusion: Momardica charantia Linn is a potential herb in the world. Bitter guard is not only used as an ingredient for cooking delicious delicacies, but it is also used for medical purposes. Bitter guard is having many activities like anti-cancer,[2] anti-diabetic,[3] anti-inflammatory,[4] anti-oxidant,[5] anti-genotoxic.[6] anti-viral,[7] wound-healing activity[8] activities. We concluded that it is also having anti-depressant activity by performing different photochemical screenings tests and also forced swimming test by using Wister albino rats at a dose of 100mg/kg and 200mg/kg and exhibited significant anti-depressant activity.

Keywords: Momordica charantia seeds, MEMC, anti-depressant activity.