Abstract

A NOVEL APPROACH FOR THE USE OF ARTEROLANE MALEATE IN TREATMENT OF MALARIA

Ankit Santosh Parulkar* and Dr. Ramakrishna Shabaraya

ABSTRACT

Malaria is one of the most prominent life threatening disease inspite of many efforts made to fight against it. There are many clinically effective anti-malarial agents but the major reasons of malaria treatment failure are due resistance development, incorrect dosing, poor drug quality, drug interactions, poor drug absorption and misdiagnosis. Current approach done in this study is to formulate a dosage form which can overcome these drawbacks. Here nanoparticles of Arterolane Maleate was formulated by solvent evaporation method using different concentration of polymers ethylcellulose, eudragit RS 100 and eudragit RL 100 and evaluated for preformulation studies, drug compatibility studies was done using FTIR. Evaluation parameters such as scanning electron microscopy (SEM), particles size analysis, zeta potential and in-vitro dissolution studies were done. The nanoparticles were obtained in the size range of 100 – 200 nm. The evaluation results obtained showed that the formulation F9 having highest polymer ratio showed the best release profile.

Keywords: malaria, nanoparticle, Arterolane Maleate, zeta potential