Abstract

EVALUATION OF ANTI-ULCER POTENTIAL OF THE SIDDHA FORMULATION PIRANDAI VADAGAM IN ASPIRIN ULCERATE RATS

G. Anitha Therese* and K. Kanakavalli

ABSTRACT

In Indian system of traditional medicine siddha system of medicine is considered to be the oldest traditional healing therapies known to the mankind since several centuries. Siddha system of medicine has versatile formulation in curing gastric ulcers as it denoted by Gunmam. The term Gunmam refers to the group of ulcerative disease occurs in the alimentary tract such as like peptic ulcers, dyspepsia, gastritis, GERD etc. According to the ancient vedic siddha physician yugi muni siddhar who was considered as a father of pathology in siddha, he categorized the ulceration in to 8 different types. It is evident that there are some medicinal plants used in siddha have potency of acting as anti-ulcer agents. The novelty of most of the siddha preparations are still not much explored and documented. Hence as a measure of exploring therapeutic potential of the novel siddha formulation Pirandai Vadagam (PV) the present study proposed to investigate the anti-ulcer property of the formulation PV in aspirin induced gastric ulcer model in rats. Results of the study has shown that animals treated with 200mg/kg of Aspirin shown increased severity in ulcer score of about 2.667 ± 0.21 and treatment with PV at the dose of 200 and 400 mg/kg significantly reduced the ulcer score and the score was found to be 1.167 ± 0.40 for 200mg/kg and 1± 0.15 for 400g/kg of PV. Further PV at the dose of 200mg/kg offers 58.47 percentage ulcer protection and 66.63% protection at 400mg/kg. It was concluded from the result of the present investigation that the formulation PV has promising anti-ulcer activity against the aspirin ulcerated rats.

Keywords: Siddha system, Pirandai Vadagam, Anti-ulcer, Aspirin, Siddhar, ulcer score.